Marine Alkaloid Derivatives that Reverse Phenotypic and Genotypic Antibiotic Resistance

Wednesday, 22 March 2017 - 4:10pm - 5:30pm
LD 010

Antibiotic resistance and the rise of antibiotic resistant pathogens are threatening the vast strides we have made over the past century in human medicine.  To combat the threatening tide of multi-drug resistant (MDR) bacteria, we have been exploring the use of small molecules based upon naturally occurring nitrogen-dense marine natural products to serve as adjuvants for antibiotic treatment regiments.  The talk will detail our efforts to develop small molecules that inhibit and disperse bacterial biofilms both in vitro and in vivo, and the application of knowledge gained through mechanistic studies to identify additional small molecules that are able to reverse both acquired and intrinsic resistance in MDR pathogens.