Special Topics in Chemistry: Solid-Phase Synthesis and Combinatorial Chemistry: Theory and Practice

CHEM 69600


This course will explore how the tools of solid-phase synthesis and combinatorial chemistry are being used to solve a wide variety of problems requiring chemical solutions. Examples range from medicinal chemistry and drug discovery to new catalyst creation, from new "chiral selectors" to new biochemical probes. The course will focus on the rationale for employing a combinatorial approach in chemical discovery. It will teach the basics of solid-phase organic chemistry, and the methodology, equipment, and analytical technology employed to use it as a tool to rapidly and effectively carry out a combinatorial approach to problem solving.