CHEM 696: Biomaterials (Special Topics)
The course will discuss general principles of biomaterials science. It includes three different sections: (1) Materials Science and Engineering of Biomaterials, (2) Biological, Biochemical, and Medical Aspects of Biomaterials, and (3) Biomaterials in Medicine. Topics of the first section are: bulk and interfacial properties of materials, classes of biomaterials (metals, polymers, hydrogels, bioresorbable and bioerodable materials, ceramics and glasses, natural materials, composites, thin films and coatings, fabrics, biofunctionalized materials). Topics of the second section focus on: protein adsorption, cell adsorption, tissue engineering, host reactions to biomaterials, degradation of biomaterials, testing of biomaterials. The last section involves: cardiovascular applications, nonthrombogenic treatments and strategies, dental implants, adhesives and sealants, ophtalmologic applications, drug delivery systems, sutures, burn dressings, bioelectrodes, biosensors, artificial organs, and perspectives in biomaterials science.
Textbook: Biomaterials Science
By B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons
Detailed Outline:
Section #1: Materials Science and Engineering of Biomaterials
á Properties of Materials (Bulk Properties, Interfacial Properties)
á Classes of Materials (Metals, Polymers, Hydrogels, Bioresorbable and Bioerodable Materials, Ceramics and Glasses, Natural Materials, Composites, Thin Films and Coatings, Fabrics, Biofunctionalized Materials)
Exam I
Section #2: Biological, Biochemical, and Medical Aspects of Biomaterials
á Proteins: Structure, Properties, and Adsorption to Surfaces
á Cells: Their Surfaces and Interactions with Materials
á Tissue, Tissue Engineering
Exam II
á Host Reactions to Biomaterials (Inflammation, Wound Healing,, Foreign Body Response, Immunological Response, Toxicity and Hypersensitivity, Blood Coagulation, Tumorigenesis)
á Degradation of Biomaterials in Biological Environment
á Testing Biomaterials
Exam III
á Cardiovascular Applications
á Nonthrombogenic Treatments and Strategies
á Dental Implants
á Adhesives and Sealants
á Ophtalmologic Applications (contact lenses)
á Drug Delivery Systems
á Sutures
á Burn Dressings
á Bioelectrodes
á Biomedical Sensors and Biosensors
á Artificial Organs
á Perspectives and Possibilities in Biomaterials Science
Final Exam