William L. Scott

Research Professor Organic and Medicinal Chemistry B.A., Williams College, 1967 Ph.D., University of California, Los Angeles, 1972 NIH Postdoctoral Fellow, Rockefeller University, 1972-73 NIH Postdoctoral Fellow, California Institute of Technology, 1974 Research Scientist in Drug Discovery at Eli Lilly 1974-2001 Phone: (317)274-6880 Email: wscott@chem.iupui.edu Research Publications

Research

The focus of Dr. Scott’s research is the development of simple and inexpensive equipment and combinatorial synthetic methodologies to quickly make large numbers of “drug-like” molecules. These compounds can be screened in biological assays to generate leads for drug discovery. His synthetic focus is on the solid-phase synthesis of conformationally constrained peptidomimetic molecules and unnatural amino acids.

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Recent Publications

W. L. Scott, J. G. Martynow, J. C. Huffman and M. J. O'Donnell "Solid- phase synthesis of multiple classes of peptidomimetics from versatile resin-bound aldehyde intermediates" Journal of the American Chemical Society 2007, 129, 7077-7088.

J. Alsina, W. L. Scott and M. J. O'Donnell "Solid-phase synthesis of α-substituted proline hydantoins and analogs" Tetrahedron Letters 2005, 46, 3131-3135.

W. L. Scott, J. Alsina, J. H. Kennedy and M. J. O'Donnell "Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics" Organic Letters 2004, 6, 1629-1632.

M. J. O'Donnell, J. Alsina and W. L. Scott "Solid-phase synthesis and utilization of side-chain reactive unnatural amino acids" Tetrahedron Letters 2003, 44, 8403-8406.

W. L. Scott, J. Alsina and M. J. O'Donnell "The manual and automated solid-phase synthesis of α-substituted prolines and homologues" Journal of Combinatorial Chemistry 2003, 5, 684-692.

W. L. Scott, M. J. O’Donnell, F. Delgado and J. Alsina “A solid-phase route to unnatural amino acids with diverse side-chain substitutions” Journal of Organic Chemistry 2002, 67, 2960-2969.

W. L. Scott, F. Delgado, K. Lobb, R. S. Pottorf and M. J. O’Donnell “Solid-phase synthesis of amino amides and peptide amides with unnatural side chains” Tetrahedron Letters 2001, 42, 2073-2076.

M. J. O'Donnell, F. Delgado, E. Domínguez, J. de Blas and W. L. Scott "Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions" Tetrahedron: Asymmetry 2001, 12, 821-828.

M. J. O'Donnell and W. L. Scott "Unnatural amino acid and peptide synthesis" in: Peptides 2000, J. Martinez and J.-A. Fehrentz, Eds., EDK: Paris, 2001, pp. 31-36.

M. J. O'Donnell, M. D. Drew, R. S. Pottorf and W. L. Scott "UPS on Weinreb resin: A facile solid-phase route to aldehyde and ketone derivatives of "unnatural" amino acids and peptides" J. Comb. Chem. 2000, 2, 172-181.