Our first area of interest is the biofunctionalization
of inorganic solids and polymeric materials with bioartificial membranes
that mimic specific properties of native biomembranes. The biofunctionalization
of substrates is of great practical and scientific interest because
it not only opens a wide field for studying biochemical processes
with surface-sensitive detection techniques but has also several
technical applications such as biosensors or biomaterials. Our main
goal is a fundamental understanding of the relationship between
molecular design and functionality of bioartificial membranes on
substrates. Specifically, we are monitoring the movement of single
proteins and lipids within the 2-dimensional matrix of bioartificial
membranes via single molecule fluorescence imaging microscopy. This
will help explain of how the membrane properties are affected by
the underlying substrate.
Our second research area has its focus on the structure-function
relationship of biomaterials. Biomaterials are synthetic materials,
which treat or replace any tissue, organ, or function of the body.
The quality of a biomaterial depends on several factors including:
its design, its properties, and its acceptance by the surrounding
tissue (biocompatibility). One research interest has the goal to
obtain a deeper understanding of how chemical and physical properties
affect the biocompatibility of potential biomaterials. Furthermore,
we are interested to know how environmental conditions and biochemical
reactions affect the biotribology properties (friction, wear, lubrication)
of these materials. Our experiments will help develop biomaterials
with novel surface properties.
Naumann, C., T. Brumm, and T. M. Bayerl (1992).
Phase transition of single phosphatidylcholine bilayers on a spherical
support studied by DSC, NMR and FT-IR. Biophys.J.63, 1314 –1319.
Dolainsky, C., T. Köchy, C. Naumann, T. Brumm,
S.J. Johnson, and T. M. Bayerl (1992). Structure and dynamics
of planar and spherical supported phospholipid bilayers. In D.R.R.
Lipowsky, K. Kremer (Ed.), Workshop on Structure and Conformation
of Amphiphilic Membranes, Jülich, Germany: Springer
C. Naumann, T. Brumm, A.R. Rennie, R.K. Thomas, J. Penfold, and
T.M. Bayerl (1995). Hydration of DPPC monolayers at the air-water
interface and its modulation by the nonionic surfactant C12E4:
A neutron reflection study. Langmuir 11, 3948 - 3952.
C. Naumann, C. Dietrich, A. Behrisch, T.M. Bayerl, M. Schleicher,
D. Bucknall, and E. Sackmann (1996). Hisactophilin mediated binding
of actin to lipid lamellae - A neutron reflectivity study of protein
membrane coupling. Biophys. J.71, 811-823.
O. Prucker, C. Naumann, J. Rühe, W. Knoll, and C.W. Frank
(1999). Photochemical attachment of polymer layers to solid surfaces
via monolayers of benzophenone derivatives. J. Am. Chem. Soc.
121, 8766-8770.
C. Naumann, C.F. Brooks, G.G. Fuller, W. Knoll, and C.W. Frank
(1999). Viscoelastic properties of lipopolymers at the air-water
interface - A combined interfacial stress rheometer and film balance
study. Langmuir 15, 7752-7761.
Naumann, C. A., Brooks, C. F., Wiyatno, W., Fuller, G. G., Knoll,
W., Frank, C.W. (2001) Rheological properties of lipopolymer-phospholipid
mixtures at the air-water interface: A novel form of two-dimensional
physical gelation. Macromolecules 34, 3024-3032. />
Naumann, C. A., Brooks, C. F., Fuller, G. G., Lehmann, T., Ruehe,
J., Knoll, W., Kuhn, P., Nuyken, O., Frank, C. W. (2001) Two-dimensional
physical networks of lipopolymers at the air-water interface:
Correlation of molecular structure and surface rheological behavior.
Langmuir 17, 2801-2806.
Naumann, C. A., Knoll, W., Frank, C.W. (2001) Hindered diffusion
in polymer-tethered membranes: A monolayer study at the air-water
interface. Biomacromolecules 2, 1097-1103.
Frank, C. W., Naumann, C. A., Knoll, W., Brooks, C. F., Fuller,
G. G. (2001)Two-dimensional physical networks of lipopolymers
at the air-water interface. Macromolecular Symposia 166, 1-12.
Ke, P. C., Naumann, C. A. (2001) Single molecule fluorescence
imaging of phospholipid monolayers at the air-water interface.
Langmuir 17, 3727-3733.
Ke, P. C., Naumann, C. A. (2001) Hindered diffusion in polymer-tethered
phospholipid monolayers at the air-water interface: A single molecule
fluorescence imaging study. Langmuir 17, 5076-5081.
Coffman, J. P., Naumann, C. A. (2002) Molecular weight dependence
of viscoelastic properties in two-dimensional physical polymer
networks of amphiphilic lipopolymer monolayers at the air-water
interface. Macromolecules 35, 1835-1839.
Naumann, C. A., Prucker, O., Lehmann, T., Ruehe, J., Knoll, W.,
Frank, C. W. (2002) The Polymer-supported phospholipid bilayer:
Tethering as a new approach toward substrate-membrane stabilization.
Biomacromolecules 3, 27-35.
