Haibo Ge
 |
| Assistant Professor
Synthetic Methodologies & Total Synthesis
|
Ph.D. University of Kansas, 2006
Postdoctoral Fellow, The Scripps Research Institute, 2006-2009
|
| Phone: |
(317) 274-6876 |
Email: |
geh@iupui.edu |
 |
Research |
|
Publications |
|
Research
Research in our group focuses on the development of metal-catalyzed carbon-carbon and carbon-heteroatom bond formation through C-H activation and total synthesis and structure-activity relationship studies of biologically active natural products.
Current research programs in our laboratory include: 1) palladium-catalyzed C-H functionalization: investigation of novel transformations on aromatic and non-aromatic heterocycles, as well as metal-catalyzed cascade reactions; 2) total synthesis and structure-activity relationship studies of ascochlorin as an inhibitor of activator protein-1 (AP-1) for selective cytotoxicity in estrogen receptor-negative breast cancer; 3) synthesis and structure-activity relationship studies of aplysamine 6 to inhibit a novel target isoprenylcysteine carboxyl methyltransferase (ICMT).
back to top
Ge, H.; Wang, J.; Kayser, M.; Himes, R. H.; Georg, G. I. Synthesis, Tubulin Assembly, and Antiproliferative Activity of 10-Ο-Acetyl-5'-hydroxybutitaxel. Bioorg. Med. Chem. Lett. 2008, 18, 6165-6167.
Turunen, B. J.; Ge, H.; Oyetunji, J.; Vasandani, V.; Desino, K.; Audus, K. L.; Himes, R. H.; Gunda I. Georg. Paclitaxel Succinate Analogues: Anionic and Amide Introduction As a Strategy to Impart Blood-Brain Barrier Permeability. Bioorg. Med. Chem. Lett. 2008, 18, 5971-5974.
Ge, H.; Niphakis, M. J.; Georg, G. I. Palladium (II) Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates. J. Am. Chem. Soc. 2008, 130, 3708-3709.
Ge, H.; Spletstoser, J. T.; Yang, Y.; Kayser M.; Georg, G. I. Synthesis of Docetaxel and Butitaxel Analogues Through Kinetic Resolution of Racemic β-Lactams with 7-Ο-Triethylsilylbaccatin III. J. Org. Chem. 2007, 72, 756-759.
Ge, H.; Vasandani, V.; Huff, J. K.; Audus, K. L.; Himes, R. H.; Seelig, A.; Georg, G. I. Synthesis and Interactions of 7-Deoxy-, 10-Deacetoxy- and 10-Deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells. Bioorg. Med. Chem. Lett. 2006, 16, 433-436.
back to top